Calzada V., Cerecetto H., Tosar J.P. (ed.) Biotherapeutics: From small to large molecules and cells

Springer Nature Switzerland AG, 2024. — 364 p. — ISBN: 978-3-031-81024-4. — Topics in Medicinal Chemistry: Volume 42This book reviews biotherapeutics from a medicinal chemistry perspective. It covers proteins, nucleic acids, low molecular weight hormones, small peptides, extracellular vesicles, gene therapy, cell-based products, and tissue-engineered products. Expert contributors provide insights into the mechanisms of action and translational processes of biotherapeutics. Particular attention is given to the latest developments in therapeutic proteins and nucleic acids. Biotherapeutic formulation developments like encapsulation, structural modifications and nanovehiculization are also presented in this book.
Divided into 15 chapters, the book begins with basic concepts and definitions of biotherapeutics from a medicinal chemistry standpoint. The following chapters focus on therapeutic proteins, monoclonal antibodies, protein production, and structural modifications. Other chapters cover topics such as antisense oligonucleotides, aptamers, mRNA, gene therapy, as well as other biotherapeutics like low molecular weight hormones and small peptides. The book concludes with an overview of biotherapeutic formulations and an authoritative discussion on regulatory aspects.Medicinal Chemistry and Biotherapeutics: Overview and Definitions
Biotherapeutics: General Introduction
Therapeutic Proteins
Monoclonal Antibodies as Biotherapeutics
Development and Production of Protein-Based Biotherapeutics in Mammalian Cells
Antisense Oligonucleotides (ASOs)
Small Interfering RNAs (siRNAs)
Aptamers
Gene Therapy
Nucleic Acids Production
Conventional and Emerging Cell Therapy Strategies
Low Molecular-Mass Hormones: Peptidic and Steroidal Hormones
Small Peptidesas Biotherapeutics
Encapsulation and Structural Modifications of Biotherapeutics
Evolution of International Standards for the Approval of Biosimilars: A Path to Flexibilities