Iniewski K. (Ed.) CMOS Biomicrosystems: Where Electronics Meet Biology

Wiley, 2011. — 499 p. — ISBN: 978-1-118-01647-3.The emerging generation of health care that offers dramatic improvements in disease detection will likely be enabled by bioelectronics, a frontier discipline at the interfaces of electronics, biology, physics, chemistry, and materials science. By integrating these diverse scientific fields, bioelectronics will revolutionize how we interact with, measure, and understand biological systems, enabling emerging technologies from DNA injection to implantable sensors in the human body. This paradigm shift will have enormous impact on improving the quality and hopefully reducing the cost of health care.
CMOS Biomicrosystems provides contemporary coverage of major advances as the well - established CMOS microelectronics technologies are employed to provide innovative solutions in the broad areas of biomedical applications. The book is an overview of the numerous new advancements in this exciting field of microelectronics that is “ meeting ” biology. It contains many applications and examples of CMOS systems already realized or being developed for providing new tools to interface to biology.
The topic of biomicrosystems is a very active research area worldwide, as the various areas in this field are enjoying considerable popularity. The book contains a broad overview of many different applications of CMOS technology and fabrications, ranging from electrocardiograph and electroencephalogram signals acquisition to molecular and cell detection to in vivo imaging systems. The book is more in the style of a reprint book, highlighting individual, self - contained chapters. In this context, the information likely will be of greatest value to those working in the field. However, the chapters are appropriately written to introduce the newcomer to the chapter topic before delving into the detailed technical topics, a benefit for the reader who is from outside the bioelectronics field.
The book is divided into three parts: Human Body Monitoring, Biosensors and Circuits, and Emerging Technologies. The fi rst part on human body monitoring starts with introducing fundamental concepts and performance key metrics, a chapter written by researchers from Imperial College London. This chapter is followed by chapters on neural signal recording written by authors from Politecnico di Milano and National Chung - Cheng University. Researchers from Samsung describe the use of RF technology for health care applications. Finally, a team from Tsinghua University covers design considerations for implantable systems.
The second part on biosensors and biocircuits starts with the fundamentals of biosensors, discussing stochastic modeling and figures of merit, a chapter written by researchers from the University of Texas at Austin. This chapter is followed by a description of CMOS and MEMS biochip technologies written by Dr. Courtois from Circuits Multi - Projects (CMP). The following chapters by authors from Polytechnic Montreal and the University of California, Los Angeles, deal with biointerfaces for lab - on - chip applications and lensfree on - chip imaging, a new tool for telemedicine. Finally, researchers from the University of California, San Diego, and Imperial College London describe monitoring systems for biomicrofluidics and stem cell culture processing.
The third part on emerging technologies starts with an introduction to futuristic biology interfacing written by researchers from Berkeley. They show three examples of the types of interfaces that link CMOS paradigms with biological systems: remote flight control of insects through implantable microsystems, pixelated interfaces to developing cells, and CMOS - compatible very high - density (VLSI) microfluidics. This chapter is followed by a description of technologies for arrayed single - cell biology authored by researchers from the University of Washington. The following chapters by authors from the University of Arkansas and Arizona State University cover an intriguing fi eld of nanoscale engineering systems; both bacterial flagellar motors and gene injection are presented. Finally, an innovative approach to early disease detection based on RF circuits is proposed by researchers from Harvard.