Maxfield F.R., Willard J.M., Lu Shuyan (eds.) Lysosomes: Biology, Diseases, and Therapeutics: Biology, Diseases, and Therapeutics

Wiley, 2016. — 562 p. — ISBN: 978-1118645154Discussing recent findings, up-to-date research, and novel strategies, the book integrates perspectives from pharmacology, toxicology, and biochemistry to illustrate the potential of lysosomes in drug discovery and development.Lysosomes: An Introduction
Lysosome Biogenesis and Autophagy
Multivesicular Bodies: Roles in Intracellular and Intercellular Signaling
Lysosomes and Mitophagy
Lysosome Exocytosis and Membrane Repair
Role of Lysosomes in Lipid Metabolism
TFEB, Master Regulator of Cellular Clearance
Lysosomal Membrane Permeabilization in Cell Death
The Lysosome in Aging‐Related Neurodegenerative Diseases
Lysosome and Cancer
The Genetics of Sphingolipid Hydrolases and Sphingolipid Storage Diseases (Pages: 209-238)
Lysosome‐Related Organelles: Modifications of the Lysosome Paradigm
Autophagy Inhibition as a Strategy for Cancer Therapy
Autophagy Enhancers, are we there Yet?
Pharmacological Chaperones as Potential Therapeutics for Lysosomal Storage Disorders: Preclinical Research to Clinical Studies
Endosomal Escape Pathways for Delivery of Biologics
Lysosomes and Antibody–Drug Conjugates
The Mechanisms and Therapeutic Consequences of Amine‐Containing Drug Sequestration in Lysosomes
Lysosome Dysfunction: An Emerging Mechanism of Xenobiotic‐Induced Toxicity
Lysosomes and Phospholipidosis in Drug Development and Regulation