Moore P.K., Whiteman M. (Eds.) Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide

Springer International Publishing, 2015. — 384 p. — ISBN: 978-3-319-18143-1.This book puts hydrogen sulfide in context with other gaseous mediators such as nitric oxide and carbon monoxide, reviews the available mechanisms for its biosynthesis and describes its physiological and pathophysiological roles in a wide variety of disease states. Hydrogen sulfide has recently been discovered to be a naturally occurring gaseous mediator in the body. Over a relatively short period of time this evanescent gas has been revealed to play key roles in a range of physiological processes including control of blood vessel caliber and hence blood pressure and in the regulation of nerve function both in the brain and the periphery. Disorders concerning the biosynthesis or activity of hydrogen sulfide may also predispose the body to disease states such as inflammation, cardiovascular and neurological disorders. Interest in this novel gas has been high in recent years and many research groups worldwide have described its individual biological effects. Moreover, medicinal chemists are beginning to synthesize novel organic molecules that release this gas at defined rates with a view to exploiting these new compounds for therapeutic benefit.Biochemistry, Molecular Biology and Chemistry
H₂S Synthesizing Enzymes: Biochemistry and Molecular Aspects
Molecular Mechanisms of Action Persulfidation (S-sulfhydration) and H₂S
Physiological Roles of Hydrogen Sulfide and Polysulfides
Cardiovascular and Urogenital Systems H₂S and Blood Vessels: An Overview
Guangdong Yang and Rui Wang
Hydrogen Sulfide and Urogenital Tract
H₂S Is a Promoter of Angiogenesis: Identification of H₂S “Receptors” and Its Molecular Switches in Vascular Endothelial Cells
Hydrogen Sulfide and Platelets: A Possible Role in Thrombosis
Inflammation and Inflammatory Disease H₂S and Inflammation: An Overview
Hydrogen Sulfide and Neuroinflammation
H₂S and the Nervous System
Brain, Learning, and Memory: Role of H₂S in Neurodegenerative Diseases
H2S and Pain: A Novel Aspect for Processing of Somatic, Visceral and Neuropathic Pain Signals
H₂S, Angiogenesis and Cancer
Hydrogen Sulfide and Cancer
Role of H₂S Donors in Cancer Biology
H₂S and Ageing
H₂S: A New Approach to Lifespan Enhancement and Healthy Ageing?
H₂S, Measurement and Possible Therapeutics?
Fluorescent Probes for H₂S Detection and Quantification
The Pharmacological Effects of S-Propargyl-Cysteine, a Novel Endogenous H₂S-Producing Compound
Phosphinodithioate and Phosphoramidodithioate Hydrogen Sulfide Donors
Medicinal Chemistry: Insights into the Development of Novel H₂S Donors